PRC in AMPK-β1−/− mice in response to furosemide, hydralazine, and isoprenaline. AMPK-β1−/− mice (open bars) and WT control mice (solid bars) were intraperitoneally injected with furosemide, hydralazine, isoprenaline, or vehicle, and PRC was measured after 30 min. n = 8–11 mice/group. *P < 0.05 compared with WT control mice under the same treatment conditions.