Table 1.
Physical data and serum and urine measurements in WT and AMPK-β1−/− mice
| WT Mice | AMPK β1−/− Mice | Number of Animals | P Value | |
|---|---|---|---|---|
| Body weight, g | 26.6 ± 3.8 | 24.0 ± 2.8 | 20 | 0.084 |
| Food consumption, mg·g body wt−1·day−1 | 164.6 ± 43.6 | 178.5 ± 27.9 | 10 | 0.330 |
| Urine output. ml/day | 1.82 ± 0.72 | 2.16 ± 0.61 | 20 | 0.421 |
| Creatinine clearance, ml·min−1·m−2 | 19.6 ± 2.3 | 25.2 ± 4.1 | 4 | 0.136 |
| Kidney weight, mg/g body wt | 9.0 ± 1.0 | 8.1 ± 0.8 | 13 (WT) and 19 (AMPK-β1−/−) | 0.010 |
| Serum measurements | ||||
| Na+, mmol/l | 174.0 ± 16.4 | 166.4 ± 14.3 | 11 | 0.930 |
| K+, mmol/l | 7.1 ± 1.6 | 6.1 ± 1.7 | 11 | 0.892 |
| Cl−, mmol/l | 109.1 ± 3.6 | 108.5 ± 4.6 | 11 | 0.861 |
| PO43−, mmol/l | 3.2 ± 0.57 | 3.2 ± 0.57 | 11 | 0.892 |
| Creatinine, mmol/l | 0.029 ± 0.00 | 0.029 ± 0.00 | 11 | 0.872 |
| Urine measurements | ||||
| Creatinine mmol/l | 2.60 ± 1.17 | 2.34 ± 1.03 | 17 | 0.559 |
| Ratio of mmol/mmol Creatinine | ||||
| Na+ | 39.7 ± 15.7 | 55.1 ± 29.7 | 17 | 0.039 |
| K+ | 38.6 ± 17.7 | 43.8 ± 22.0 | 17 | 0.420 |
| Cl− | 47.1 ± 16.5 | 57.1 ± 20.4 | 17 | 0.285 |
| Ca2+ | 0.50 ± 0.27 | 0.48 ± 0.28 | 17 | 0.757 |
| Mg2+ | 5.22 ± 1.04 | 4.24 ± 1.44 | 9 | 0.136 |
| PO43− | 15.1 ± 9.73 | 19.1 ± 11.1 | 17 | 0.257 |
| Urea | 235.4 ± 40.7 | 230.7 ± 61.1 | 17 | 0.855 |
Values are means ± SD. WT, wild type; AMPK-β1−/−, AMP-activated protein kinase-β1 knockout.