Table 3.
Urine measurements in WT and ACC1-KIS79A mice fed a normal or Na+-deficient diet for 2 days
| WT Mice | ACC1-KIS79A Mice | Number of Animals | P Value | |
|---|---|---|---|---|
| Normal Na+ diet urine measurements, ratio of electrolytes/creatinine | ||||
| Na+ | 44.5 ± 15.1 | 45.9 ± 10.4 | 11 | 0.834 |
| K+ | 29.9 ± 8.0 | 39.6 ± 11.9 | 11 | 0.118 |
| Cl− | 28.5 ± 12.6 | 40.3 ± 14.9 | 11 | 0.182 |
| Ca2+ | 0.68 ± 0.37 | 0.81 ± 0.41 | 11 | 0.404 |
| Mg2+ | 4.80 ± 0.85 | 4.93 ± 0.86 | 11 | 0.357 |
| PO43− | 5.84 ± 3.22 | 8.48 ± 2.78 | 11 | 0.309 |
| Urea | 188.2 ± 46.0 | 229.7 ± 67.2 | 11 | 0.194 |
| Low-Na+ diet urine measurements, ratio of mmol/mmol creatinine | ||||
| Na+ | 3.06 ± 1.05 | 3.58 ± 1.46 | 7 | 0.281 |
| K+ | 22.4 ± 4.07 | 30.3 ± 8.79 | 7 | 0.532 |
| Cl− | 3.60 ± 1.17 | 4.90 ± 1.79 | 7 | 0.583 |
| Ca2+ | 0.27 ± 0.08 | 0.29 ± 0.10 | 7 | 0.976 |
| Mg2+ | 1.52 ± 0.88 | 2.74 ± 1.06 | 7 | 0.770 |
| PO43− | 14.8 ± 2.35 | 19.8 ± 3.79 | 7 | 0.566 |
| Urea | 204.3 ± 22.1 | 210.0 ± 28.7 | 7 | 0.724 |
Values are means ± SD. ACC1-KIS79A mice, mice with a point mutation of the inhibitory AMPK phosphosite in acetyl-CoA carboxylase 1.