Lordosis quotient (mean ± SEM) of CD-1 female mice shipped at 3, 4, 6, 8 and 10 weeks old on Test 4 and Test 5. a, lordosis quotient significantly lower than females shipped at 3 weeks old (p < 0.05); b, significantly lower than females shipped at 4 weeks old (p < 0.05); c, significantly lower than females shipped at 10 weeks old (p < 0.05). Reprinted from (Ismail et al., 2011) with permission of Elsevier, Copyright 2011.