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Impaired larval locomotor activity in unc-104bris larvae. (A) unc-104bris larvae are slower than wild-type larvae. unc-104bris/− larvae are largely immobile and die in the late third instar stage. (B) Larvae in the act of crawling. No dystonic posterior paralysis is observed. unc-104bris/− larvae display a body posture defect that can be rescued by panneuronal expression of unc-104mCherry. The SEM is shown as a box, the SD as a black line. ***P < 0.001.
