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. 2013 Jun 21;305(5):H676–H686. doi: 10.1152/ajpheart.00797.2012

Table 1.

Body weight and echocardiographic characteristics of female F344 rats

6 Mo (n = 7) 18 Mo (n = 9) 22 Mo (n = 8) P Value (One-Way ANOVA)
Body weight, g 203.4 ± 8.7 307.1 ± 7.7* 327.6 ± 8.7* <0.0001
HR, beats/min 326.4 ± 12.6 321.4 ± 11.1 294.9 ± 12.6 0.185
FS, % 52.2 ± 3.1 51.4 ± 2.8 47.2 ± 2.9 0.453
IVSd, mm 1.8 ± 0.1 1.7 ± 0.1 1.8 ± 0.1 0.553
IVSs, mm 2.8 ± 0.2 3.0 ± 0.1 2.9 ± 0.1 0.592
LVIDd, mm 5.3 ± 0.2 6.7 ± 0.2* 6.6 ± 0.2* <0.0001
LVIDs, mm 2.5 ± 0.2 3.2 ± 0.2 3.5 ± 0.2* 0.025
LVPWd, mm 1.8 ± 0.1 1.9 ± 0.1 1.8 ± 0.1 0.775
LVPWs, mm 2.7 ± 0.2 3.0 ± 0.1 2.7 ± 0.1 0.282
dBA, mm 4.6 ± 0.4 4.5 ± 0.3 5.1 ± 0.3 0.473
E/E' 29.0 ± 6.3 41.4 ± 6.3 37.3 ± 6.8 0.379

Values are means ± SE. HR, heart rate; FS, fractional shortening; IVSd, diastolic thickness of the septum; IVSs, systolic thickness of the septum; LVIDd, diastolic left ventricular inner diameter; LVIDs, systolic left ventricular inner diameter; LVPWd, diastolic thickness of the left ventricular posterior wall; LVPWs, systolic thickness of the left ventricular posterior wall; dBA, normal distance between the imaging planes; E/E′,ratio of peak early mitral valve flow to peak early mitral valve septal annulus velocity.

*

Signficant difference vs. 6-mo values (Tukey's honestly significant difference; P < 0.05).