TABLE III.
Sequencing Results (Chromosomally Normal CDH Cohort)
Gene | Location | Position (hg19) | Variant | Change | PolyPhen2 (score) | Phenotype | Inheritance |
---|---|---|---|---|---|---|---|
SOX7 | Exon 2 | 10,583,367 | C>A | p.A350S | Benign (0.014) | Isolated CDH | Paternal |
SOX7 | Exon 2 | 10,583,616 | C>T | p.G267S | Benign (0.049) | CDH, ASD | Not maternala |
SOX7 | Exon 2 | 10,583,657 | C>T | p.C253Y | Prob. damaging (0.975) | Isolated CDH | Maternal |
GATA4 | Enhancer | 11,518,562 | A>T | n.a. | n.a. | CDH, VSD | Not maternala |
GATA4 | Enhancer | 11,518,594 | A>C | n.a. | n.a. | CDH, minor anomalies | Maternal |
NEIL2 | Exon 2 | 11,628,978 | delA | p.R8Gfs*51 | n.a. | Isolated CDH | Maternal |
NEIL2 | Exon 3 | 11,637,312 | G>C | p.S115C | Benign (0.282) | Isolated CDH | Not maternala |
n.a., not applicable.
Not maternal, paternal sample unavailable.