Table 2.

Targets inhibited by kinase inhibitors. Data are from each KI package insert; KIs that are not known to inhibit multiple kinases are not listed.

	Agent
Kinase Inhibitor	Regorafen ib	Pon atin ib	Dasat inib	Soraf enib	Vemura fenib	Vandet anib	Caboza ntinib	Pazop anib	Sunit inib	Nilot inib	Bosut inib	Imati nib	Crizot inib
PDGFR	×	×	×	×				×	×	×		×
c-Kit	×	×	×	×			×	×	×	×		×
VEGFR	×	×		×		×	×	×	×
RET	×	×		×		×	×		×
Abl	×	×	×							×	×	×
Abl T315I		×
EGFR						×
EPHR	×	×	×			×
BRAFV60 0E	×			×	×
CRAF(raf-1)	×			×	×
Src		×	×			×					×
BRAF				×	×
CSF-1R									×	×
DDR	×									×
FGFR	×	×						×
FLT3		×		×			×		×
Hck			×								×
Lck			×					×
TIE2	×	×				×	×
ACK1					×
Alk													×
ARAF					×
AXL							×
BRK						×
c-Fms								×
FGR					×
FYN			×
Itk								×
Jak
Lyn											×
MAP4K5					×
MET							×						×
Ptk5	×
ROS1													×
Sapk2	×
SCF												×
Smoothened SRMS					×
Trk2A	×
TRKB							×
Yes			×

Abbreviations: PDGFR, platelet derived growth factor receptor; VEGFR, vascular endothelial growth factor receptor; RET, rearranged during transfection; EGFR, epithelial growth factor receptor; EPHR, ephrin receptor; SRC, rous sarcoma oncogene cellular; CSF-1R, colony stimulating factor 1 receptor; DDR, discoidin domain receptor; FGFR, fibroblast growth factor receptor; FLT3, Fms-like tyrosine kinase 3; Lck, lymphocyte-specific protein tyrosine kinase; Abl, Ableson leukemia oncogene; Jak, Janus-family tyrosine kinase; ACK1, activated CDC42 kinase 1; Alk, anaplastic lymphoma kinase; BRK, breast tumor kinase; c-Fms, cellular homolog of feline sarcoma virus; FGR, feline sarcoma viral; Itk, IL2-inducible T-cell kinase; MAP4K5, mitogen-activated protein kinase; Sapk2, stress-activated protein kinase; SCF, Skp, Cullin, F-box containing complex; SRMS, src-related kinase; TRKB, tyrosine-related kinase B; Yes; Yamaguchi sarcoma virus oncogene.