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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Curr Probl Cancer. 2013 May-Jun;37(3):110–144. doi: 10.1016/j.currproblcancer.2013.06.001

Table 5.

Examples of medications that are substrates for CYP enzymes with narrow therapeutic windows.

Type of Medication Name Adverse Reaction
Antiarrhythmic

  • Bepridil

  • Flecainide

  • Lidocaine

  • Mexiletine

  • Amiodarone

  • Quinidine

  • Propafenone

 Risk of QT interval prolongation and Torsade de Pointes
Ergot Derivatives

  • Dihydroergotamine

  • Ergonovine

  • Ergotamine

  • Methylergonovine

  • Risk of severe vasospasm

  • Risk of peripheral or cerebral ischemia

  • Immune

  • Modulators

  • Cyclosporine

  • Tacrolimus

  • Sirolimus

  • Risk of nephrotoxicity

  • Risk of neurotoxicity
Miscellaneous

  • Quetiapine

  • Risperidone

  • Clozapine

  • Atomoxetine

 Increased toxicity
Neuroleptics Pimozide Risk of QT prolongation