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Scaffold and chondrocyte morphology on aligned (a–d) and random (e–h) fiber scaffolds. Chondrocyte morphology was dramatically affected by fiber orientation (b, f). Immunohistochemical staining revealed intense staining for type II collagen matrix (c, g) with minimal type I collagen staining (d, h). Actin cytoskeleton=red; type I/II collagen=green, cell nuclei=blue; scale bar=20 μm. Color images available online at www.liebertpub.com/tea
