Table 1.

Blood and urine electrolytes and 24-h urinary aldosterone level in WNK1^+/i1lox and WNK1^+/FHHt mice at baseline

Electrolytes	WNK1+/i1lox (n = 8)	WNK1+/FHHt (n = 8)
Plasma
Na+ (mmol/L)	149.6 ± 0.5	151.4 ± 0.5*
K+ (mmol/L)	4.55 ± 0.15	6.00 ± 0.27†
Cl− (mmol/L)	112.1 ± 0.3	116.3 ± 0.3†
pH	7.31 ± 0.02	7.21 ± 0.03*
HCO3− (mmol/L)	23.5 ± 0.8	18.4 ± 0.03‡
Ca2+ (mmol/L)	2.18 ± 0.02	2.18 ± 0.03
Mg2+ (mmol/L)	0.91 ± 0.03	0.90 ± 0.03
PO43− (mmol/L)	2.82 ± 0.17	2.81 ± 0.10
Hematocrit	47.6 ± 1.6	46.2 ± 1.3
Urine
Na+ (mmol/mmol Creat)	35.9 ± 3.1	35.4 ± 2.2
K+ (mmol/mmol Creat)	114.1 ± 8.2	114.2 ± 9.9
Cl− (mmol/mmol Creat)	56.9 ± 3.9	56.9 ± 4.6
NH4+ (mmol/mmol Creat)	7.98 ± 1.17	6.68 ± 0.54
Ca2+ (mmol/mmol Creat)	0.37 ± 0.04	0.98 ± 0.13‡
Mg2+ (mmol/mmol Creat)	6.63 ± 1.10	7.86 ± 0.73
PO43− (mmol/mmol Creat)	25.6 ± 2.2	23.6 ± 1.6
24-h aldosterone (pmol)	14.6 ± 2.0	27 ± 1.9†
GFR (µL/min)	142.3 ± 12.6	122.1 ± 12.6

Creat, creatinine; GFR, glomerular filtration rate.

^*P < 0.05 compared with the control group.

^†P < 0.0005 compared with the control group.

^‡P < 0.005 compared with the control group.