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Expression of D239Y hNTH1 induces chromosomal aberrations. Metaphase spreads were prepared from early passage MCF10A pools expressing either WT or D239Y as described in Experimental Procedures. (A) Column graph showing that cells expressing D239Y had significantly increased levels of fusions and chromosome breaks. (B) Arrows point to examples of fusions observed in cells expressing D239Y. (C) Arrows point to examples of chromosome breaks in cells expressing D239Y hNTH1.
