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Ratios between pool sizes of SAMHD1-silenced and control lung fibroblasts. (A) Proliferating cultures transfected for 24 (white), 48 (gray), or 72 (black) h with control or anti-SAMHD1 siRNAs. Data are from three independent experiments. (B) Quiescent cultures of lung (broad stripes), WT (gray), or p53R2-mutated (thin stripes) skin fibroblasts transfected for 10 d with siRNAs during serum starvation. Data are from four to six experiments per cell line. All bars are SEMs.
