Fig. 2.

Replicons with proline at amino acid 328 have increased CsA susceptibility than serine in both genotype 1a and 1b lineages. (A) Transient replication of Con1bLN-post-C replicon in presence (dashed line) and in absence (solid line) of CsA after mutating amino acids at position 315, 328, and 442 similar to patient C pre-transplant sequences. (B) Percent inhibition of HCV replicons are presented at 96 h post RNA electroporation by comparing CsA treated vs untreated luciferase data as in 2A.