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CsA sensitivity of natural variants at position 328 present in different HCV genotypes. (A) The Con1bLN-5AH77 chimeric replicon was mutated to contain Ala, Ser, Met, Ile and Arg at position 328 and their replication efficiency in presence (dotted line) and in absence (solid line) of CsA at different time points. (B) Percent inhibition of HCV replicons are presented at 96 h post RNA electroporation by comparing CsA treated vs. untreated luciferase data as in (A).
