Table 2.

Physicochemical properties and pharmacokinetic parameters of selected antiretroviral drugs [31–39].

Drug	Solubility	pKa	log P	BCS classification	Half-life	% Bioavailability
Tenofovir	13.4 mg/ml	1.3; 7.9; 3.0; 5.3	−1.1	Class III	17	25–39
Emtricitabine	112 mg/ml	2.63	−0.43	Class I	10	93
Efavirenz	<10 μg/ml	10.2	3.68	Class II	40–50	42–80
Nevirapine	100 μg/ml	2.8	2.05	Class II	25–30	>90
Dapivirine	<10 μg/ml	5.8	5.27	Class II	N.A.	N.A.
Etravirine	<10 μg/ml	3.5	5.2	Class IV	30–40	N.A.
Rilpivirine	<10 μg/ml	5.6	4.86	Class II	34–55	24 (monkeys)
Raltegravir	<1 mg/ml	∼1.25	1.06	Class II	9	∼65%
Maraviroc	∼1 mg/ml	3.3, 7.9	4.37	Class III	14–18	23–33

N.A., not available.