Table 1. Median Inhibitory Concentrations (IC50) for Human Recombinant CYPs for Black Cohosh (BC) Extracts (μg/ml) and Pure Compounds (μM).
| Plant Extract | CYP1A2 | CYP3A4 | CYP2C9 | CYP2D6 |
|---|---|---|---|---|
| BC-80% ethanol | 31.4 | 45.8 | 35.5 | 75.0 |
| BC-75% ethanol | 38.8 | 48.1 | 50.0 | 76.7 |
| BC-40% isopropanol | 21.2 | 35.3 | 23.6 | 48.2 |
| CR-A1 | na | 51.3 | 40.5 | 32.2 |
| Actein | na | 35.2 | 25.0 | 51.1 |
| Deoyxactein2 | na | 28.7 | 25.9 | 100.0 |
| Fukinolic acid | 1.8 | 7.2 | 7.1 | 5.4 |
| CAA3 | 7.2 | 9.7 | 8.3 | 9.0 |
| CAB4 | 7.35 | 9.8 | 12.5 | 12.6 |
1
Cimiracemoside A.
2
Deoxyactein = 23-epi-26-deoxyactein.
3
CAA = Cimicifugic acid A.
4
CAB = Cimicifugic acid B.
na: not active at concentrations of 1-100 μg/ml; each IC50 concentration is the result of three experiments in triplicate.