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. 2013 Sep 3;2:e00036. doi: 10.7554/eLife.00036

Table 1.

Comparison of characteristics of the IPSCs or PRPSCs cells across species

DOI: http://dx.doi.org/10.7554/eLife.00036.020

Stem Cell markers Self-renewal Pluripotency
iPSC or PRPSC cells Morphology Alkaline phosphatase Induced endogenous homologs Exogenous silencing Gene expression Proliferation Telomerase EB formation/ Teratoma Gene expression Chimera formation
Mouse ESC-like clusters YES Oct4, Sox2, c-myc, Klf4 YES Nanog Vasa SSEA-1 YES YES large aggregates three germ lines YES
Chicken ESC-like clusters YES Oct4, Sox2, c-myc, −Klf4 YES Nanog Vasa SSEA-1 YES YES large aggregates/ Teratomas formed three germ lines YES
Quail ESC-like clusters YES Oct4, Sox2, c-myc, −Klf4 YES Nanog Vasa SSEA-1 YES YES large aggregates /Teratomas formed three germ lines ND
Finch ESC-like clusters YES Oct4, Sox2, c-myc, −Klf4 YES Nanog Vasa SSEA-1 YES YES small aggregates three germ lines ND
Zebrafish ESC-like clusters YES Oct4, Sox2, c-myc, −Klf4 YES - Nanog Vasa SSEA-1 YES YES small aggregates three germ lines YES
Drosophila Darker, some clusters YES Oct4 (VVL), SoxN, d-myc, −Luna (klf4) ND Vasa Dichaete Escargot Snail YES NA small aggregates NA ND

A large number of similarities are found. Species differences are highlighted in bold. NA, not applicable; ND, not done.