Fig. 1. Effects of GS on TPA-induced ear edema. GS (0.5-2% (w/v)) was applied topically to the ear of mice at the same time as a TPA application (2.5 μg/ear; A B) or orally administered (5-20 mg/kg; C D). Ear edema was measured 4 h after application of TPA.Data are the means ± SD of 10 animals. *p<0.05 relative to the control group was considered to be signifi cant. Dexamethasone or hydrocortisone was used as a positive control.