Fig. 4. Tgase-2 involvement in COX-2 expression after TPA-in-duced ear edema. Two experimental groups included three or two wild type mice or Tgase-2 (-/-) mice/group. Group 1 received ac-etone group 2 received TPA. Edema was induced in both ears of each mouse by topical application of 2.5 μg TPA dissolved in 25 μl of acetone to the inner ear surfaces. (A) Effects of TPA on Tgase-2 and COX-2 expression on ear skin of wild type mice or Tgase-2 (-/-) mice. (B) Scheme of involvement of Tgase-2 and effects of glucos-amine on TPA-induced COX-2 expression.
