Table 2.

Growth inhibitory effects mediated by daphnane diterpenoids and gemcitabine in drug-resistant cell lines

Cell line	IC50 (nM)
	YL	YH	YG	Gem	Gef	Erl
A549	7.0	9.7	24.7	41.7	nd*	nd*
A549-Gem	9.4	15.2	24.3	1,300	nd*	nd*
H292	3.7	6.2	5.1	nd*	16.2	26.0
H292-Gef	<0.2	<0.2	<0.2	nd*	646.1	189.0
H292-Erl	0.4	<0.2	<0.2	nd*	464.2	954.8

^*nd: not detected, Gem: gemcitabine, Gef: geftinib, Erl: Erlotinib.