Table 1.

NOX isoenzymes in mammalian cells

Type	Domain structure	Distribution	Regulatory factors	Functions
Nox1 (Mox-1)	Inducible, Flavo-protein, transmembrane cluster	Colon, VSMC, prostate	NOXO, NOXA, and p22phox	Proliferation response (Lee et al., 2009)
Nox2 (gp91phox)	Flavo-protein, transmembrane cluster	Phagocyte	P47phox, p67phox, p40phox, Rac1/2	Host defense (Bedard and Krause, 2007)
Nox3	Flavo-protein, transmembrane cluster	Fetal kidney	Not determined	Unclear (Bedard and Krause, 2007)
Nox4 (Renox)	Flavo-protein, transmembrane cluster	Kidney, osteoclasts, ovary, eye, widespread	Not determined	Oxygen sensing, iron transport, host defense (Bedard and Krause, 2007)
Nox5	EF hands, Flavo-protein, transmembrane cluster	Lymph nodes, testis, mammary gland, cerebrum	Calcium	Fertilization (Musset et al., 2012)
Duox1, Duox2 (p138Tox)	Peroxidase, EF hands, Flavo-protein, transmembrane cluster	Thyroid, cerebellum, colon, lung, prostate, pancreatic islets	Calcium	Hormone synthesis (Milenkovic et al., 2007)