Table 4.
Prx isoenzymes in mammalian cells
| Type | Structure | Distribution | Functions |
|---|---|---|---|
| PrxI (2-Cys) | Dimer | Cytosol, nucleus | Signal regulation (c-Abl, c-Myc, GDE2, p38, etc) (Rhee et al., 2012) |
| PrxII (2-Cys) | Decamer (Basic unit: dimer) | Cytosol, nucleus | Signal regulation (PDGF, VEGF, LPS, etc) (Choi et al., 2005) |
| PrxIII (2-Cys) | Dimer | Mitochondria | Apoptosis (Chang et al., 2004) |
| PrxIV (2-Cys) | Dimer | ER, extracellular | ER foldase, Epididymal spermatozoa (Nguyen et al., 2011) |
| PrxV (atypical 2-Cys) | Dimer | Mainly peroxisome, some in cytosol and mitochondria | Unclear (Wood et al., 2003) |
| PrxVl (1-Cys) | Monomer | Cytosol | Unclear (lung phospholipid metabolism and cellular invasive/metastatic potential) (Wood et al., 2003) |