Figure 3. .

The role of TNFα in the regulation of ICAM-1. ICAM-1 ELISA results for REC treated with sc siRNA, TNF-α siRNA (A), or etanercept (B) and melphalan. Neither TNF-α siRNA nor etanercept-reduced ICAM-1 levels after melphalan treatment. (C) Cell Death ELISA results for REC treated with etanercept and/or melphalan. While etanercept did reduce melphalan-induced REC apoptosis, it did not reach statistical significance. *P < 0.05 versus control. #P < 0.05 versus melphalan only. Data are mean ± SEM. n = 4.