Table 2.

Predictive Models Constructed to Identify Couples at Increased Likelihood of Being HSV-2-concordant Negative or HSV-2-discordant, Relative to HSV-2-concordant Positive Couples

	HSV-2-Concordant Negative Couples				HSV-2-Discordant Couples
	OR	(95% CI)	aORa	(95% CI)	OR	(95% CI)	aORa	(95% CI)
Younger age	1.12**	(1.07–1.17)	1.15**	(1.08–1.23)	1.06**	(1.03–1.09)	1.05**	(1.01–1.09)
Female HIV-1-infected	2.50**	(1.42–4.38)	1.78	(.92–3.44)	1.97**	(1.20–3.21)	1.54	(.90–2.63)
Years living together	0.93**	(.88–.97)	1.10*	(1.00–1.21)	0.94**	(.91–.98)
Formal Residence	1.58	(.94–2.66)	1.79	(.94–3.39)	0.77	(.48–1.23)
Female partner sexual debut >15 y old	2.90*	(1.24–6.78)	2.84*	(1.03–7.85)	0.92	(.52–1.61)
Male partner sexual debut >15 y old	0.90	(.50–1.65)			1.24	(.70–2.21)
No unprotected sexb	1.45	(.76–2.79)	1.71	(.77–3.80)	0.74	(.44–1.24)
No outside partners	6.24	(.80–48.50)	6.75	(.47–96.13)	1.34	(.49–3.62)
Desire additional childrenc	2.72**	(1.59–4.66)	2.04*	(1.00–4.13)	0.59	(1.00–2.55)
Fewer no. of children c	1.48**	(1.19–1.83)	1.27	(.91–1.78)	1.34**	(1.13–1.59)	1.22*	(1.01–1.48)
No hormonal contraceptive use	3.42**	(1.39–8.43)	3.35*	(1.24–9.06)	0.96	(.54–1.71)
Male circumcised	1.39	(.73–2.62)	1.77	(.83–3.80)	1.41	(.79–2.51)	1.68	(.89–3.18)
CD4 count	1.06	(.95–1.18)			1.10	(1.00–1.21)
Decreasing viral load	1.26*	(1.01–1.57)	1.28	(.97–1.70)	1.24*	(1.03–1.50)	1.27*	(1.03–1.56)

Couples in which either or both partners had equivocal HSV-2 results were excluded from this analysis. Age is based on the age of the oldest partner in the couple, and the OR for age is per year younger. The OR for CD4 count is per 100 cells/µL. The OR for viral load is per log₁₀ RNA copies/mL decrease.

Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; HIV, human immunodeficiency virus; HSV, herpes simplex virus; OR, odds ratio.

^a Model selected based on forward stepwise selection.

^b With study partner in the past 3 months.

^c With study partner.

*P < .05.

**P < .01.