Skip to main content
. Author manuscript; available in PMC: 2013 Sep 4.
Published in final edited form as: Nature. 2012 Dec 23;493(7434):694–698. doi: 10.1038/nature11779

Figure 3. Select phylogenetic clusters enriched with hits from proteomic and functional genomic small RNA screens.

Figure 3

A. The phylogenetic profile matrix was clustered and a Max Ratio score (MRS) was calculated for every protein in each screen; 117 proteins scored significantly in miRNA (56 genes) or siRNA (75 genes) functional genomic screens, or both (14 genes). Middle panel, black tick, hit in screens; gray tick, significant MRS. B. Blue boxes, the 23 known small RNA pathway genes identified. C. From the 117 genes predicted by the phylogenetic profile, 28 genes (blue bars) show defects in siRNA silencing (p-value < 3x10-15).