. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2012 Jul 27;62(1):67–83. doi: 10.1111/j.1467-9876.2012.01048.x

Table 4.

Maximum likelihood estimates from AFT models for residual time to death following disease being declared resistant to induction (T^RD), time to disease progression following complete remission (T^CP), and time to death from progression (T^PD). Each parameter estimate is given with 95% confidence interval limits subscripted on the left and right.

Distribution	Time
Distribution	T^RD Exponential	T^CP Log-logistic	Lognormal T^PD
Intercept	_−6.31 − 1.32_3.68	_6.498.11_9.73	_−0.721.25_3.23
Frontline therapy
FAI vs. FAI+G+ATRA	_−0.570.64_1.85	_−0.420.17_0.76	_−0.86 − 0.21_0.45
FAI+ATRA vs. FAI+G+ATRA	_0.551.83_3.10	_−0.280.29_0.86	_−0.090.50_1.09
FAI+G vs. FAI+G+ATRA	_0.872.83_4.80	_0.030.62_1.21	_−0.300.27_0.84
Cytogenetic Group^*
0 vs. 2	_−0.770.29_1.36	_−0.340.03_0.41	_−0.56 − 0.05_0.45
1 vs. 2	_−0.460.49_1.44	_−0.95 − 0.52_−0.10	_−0.90 − 0.32_0.26
Age (per year)	_−0.05 − 0.01_0.03	_−0.006 − 0.004_0.014	_−0.04 − 0.03_−0.01
log(Time to resistance)	_0.111.20_2.30	–	–
log(Time to CR)	–	_−1.29 − 0.83_−0.37	–
log(Time to disease progression)	–	–	_0.550.85_1.16
Salvage therapy
HDAC ( vs. others)	_−4.07 − 1.61_0.85	_−0.94 − 0.34_0.27	_−0.84 − 0.39_0.06
Interaction between induction and salvage therapy
FAI₋HDAC (vs others)	_−2.310.28_2.88	_−0.13 − 0.80_1.73
[FAI+ATRA]₋HDAC (vs others)	_−0.991.66_4.31	_−0.220.64_1.51
[FAI+G]₋HDAC (vs others)	_1.024.25_7.48	_0.371.20_2.03
Scale		_0.340.40_0.49	_0.850.99_1.15

0 = (“DIP,-Y”, “IM”), 1=“−5,−7”, 2=(“+8”, “11Q”, “INV16”, “T(8,21)”, “MISC”).