FIGURE 4.

Inflammatory autoimmune disease in p52 transgenic mice is lymphocyte autonomous. Splenocytes from 7-month-old p52 transgenic and wild-type (WT) mice (n = 6 for each genotype) were individually transferred into sublethally irradiated Rag1^−/− mice. Three months after transfer, the Rag1^−/− recipients were examined for anti-dsDNA autoantibody in the serum (A), infiltration in the lung (B, left panels), and IgG containing immune complexes in the kidney (B, right panels). Only the Rag1^−/− recipients of p52 splenocytes showed evidence of autoimmune inflammation. Student’s t test was used for statistical analysis (A), with p values indicated. H&E, hematoxylin and eosin; IF, immunofluorescent. Scale bars, 50 μm.