FIGURE 5.

Expansion of peripheral lymphocyte populations in p52 transgenic mice. A, splenomegaly in p52 transgenic (Tg) mice at ages of 6–24 weeks, with the spleens from age-matched wild-type (WT) mice as control. B–D, expansion of splenic lymphocyte populations in p52 mice. Shown are numbers of total splenic T and B cells (B), CD4⁺ and CD8⁺ T cells (C), and CD4⁺ CD69⁺ activated helper T cells (D) in 6–24-week-old p52 transgenic mice and their age-matched wild-type littermates. The data in A–D represent the means ±S.D. of spleens or cells from six mice of each genotype. Student’s t test was used for statistical analyses, with p values indicated.