Table 3. Distributions of genotypes and alleles for the TRPM6, TRPM7, and TRPM8 gene polymorphisms between the case and control groups.
| Gene |
Genotypes/ Alleles | Controls | n* | Cases with POAG | n* | P value |
|---|---|---|---|---|---|---|
| SNP | ||||||
| TRPM6 |
GG/GA/AA |
114/64/4 |
182 |
123/52/4 |
179 |
0.4588 |
|
rs3750425 (Val1388Ile) |
G/A |
292/72 |
298/60 |
0.3403 |
||
| TRPM6 |
GG/GA/AA |
56/73/52 |
181 |
35/88/52 |
175 |
0.0463 |
|
rs2274924 (Lys1579Glu) |
G/A |
185/177 |
158/192 |
0.1293 |
||
| TRPM7 |
CC/CG/GG |
179/3/0 |
182 |
179/0/0 |
179 |
0.248 |
|
rs77165588 |
C/G |
361/3 |
358/0 |
0.249 |
||
| TRPM8 |
CC/CT/TT |
125/51/6 |
182 |
124/53/2 |
179 |
0.3646 |
|
rs1016062 |
C/T |
301/63 |
301/57 |
0.689 |
||
| TRPM8 |
CC/CT/TT |
58/86/38 |
182 |
66/74/39 |
179 |
0.4955 |
|
rs2362294 |
C/T |
202/162 |
206/152 |
0.6314 |
||
| TRPM8 |
CC/CT/TT |
100/67/14 |
181 |
99/63/16 |
178 |
0.8885 |
|
rs6431648 |
C/T |
267/95 |
261/95 |
0.9603 |
||
| TRPM8 |
AA/AG/GG |
116/58/8 |
182 |
111/63/5 |
179 |
0.6113 |
|
rs2362295 |
A/G |
290/74 |
285/73 |
0.9837 |
||
| TRPM8 |
GG/GC/CC |
125/50/7 |
182 |
129/44/6 |
179 |
0.7796 |
|
rs10803666 |
G/C |
300/64 |
302/56 |
0.5484 |
||
| TRPM8 |
GG/GA/AA |
96/66/20 |
182 |
79/85/15 |
179 |
0.0939 |
|
rs10490018 |
G/A |
258/106 |
243/115 |
0.427 |
||
| TRPM8 |
GG/GA/AA |
105/63/14 |
182 |
108/61/10 |
179 |
0.699 |
|
rs2052029 |
G/A |
273/91 |
277/81 |
0.5083 |
||
| TRPM8 |
CC/CT/TT |
125/50/6 |
181 |
130/41/8 |
179 |
0.5318 |
|
rs2215173 |
C/T |
300/62 |
301/57 |
0.7376 |
||
| TRPM8 |
GG/GA/AA |
126/50/6 |
182 | 128/42/8 |
178 | 0.621 |
| rs6740118 | G/A | 302/62 | 298/58 | 0.8676 |
*Numbers do not always add up to total numbers because of missing values on the BioMark dynamic array system. SNP, single nucleotide polymorphism. POAG, primary open-angle glaucoma.