Table 1.

Early work on pancreas regeneration

Year	Author	Species	Procedure	Observations
1683	Brunner	D	PPx, PDL	polyuria, polydipsia, polyphagia, transient diabetes
1856	Bernard	D	duct occlusion	glandular atrophy, absence of diabetes
1879	Langendorff	birds	PDL	glandular atrophy, absence of diabetes
1884	Arnozan and Vaillard	R	PDL	accumulation of unidentified cells, possibly islets acinar degeneration, accumulation of connective and fatty tissues
1887	Vasssale	R	PDL	disappearence of acini, persistence of islets
1889	Von Mering, Minkowski	D	complete Px	diabetes, glycosuria, polyuria, death after few weeks
1900	Schulze	GP	ligation of pancreas	complete atrophy of the ligated portion, no glycosuria parenchyma sclerosis, no changes in islets, fibrous tissue
1901	Mankowski	GP	ligation of pancreas	atrophy of islets and acini
1902	Laguesse, de la Roche	R	PDL	atrophy of the exocrine parenchyma, transformed into fat islets intact
1902	Ssobolew	D, C, R	PDL	gradual atrophy and destruction of acinar cells islet cells intact for weeks, no glycosuria
1905	Lombroso	D	ligation duct	no changes or very slight atrophy
1905	Herxheimer	Ch	ligation	parenchyma preserved, islet hyperplasia
1906	Scott	Hu	ductal occlusion	acinar tissue replaced by connective tissue islets preserved, no glycosuria
1906	DeWitt	C	PDL	islets preserved ductal and acinar degeneration, accumulation of connective tissue
1906	Tchassownikow	R	PDL	islets preserved, exocrine pancreas transformed into fatty tissue
1908	Diamare	D	oil injection	glandular atrophy, few acini preserved but mostly degenerated numerous large islets
1908	Gelle	R	PDL	acino-insular transitions, numerous islets left in fat tissue
1908	Niemann	D	PDL	rapid atrophy of acinar tissue, islets preserved
1908	Kyrle	D, GP	PPx	mitoses in acini and islets, large islets islets and acini budding from duct, no transition forms
1909	MacCallum	D	PDL	acinar atrophy, persisting islets but not precisely identified transient glycosuria, diabetes after removal of the ligated portion
1909	Tiberti	Ds	PDL	islets and acinar tissue preserved
1911	Pratt and Spooner	D	PDL	almost total destruction of pancreatic tissue acini and islets disappeared
1911	Bensley	GP	PDL	acinar degeneration, endocrine regeneration islets arise from the duct
1912	Kirkbride	GP	PDL	confirmed MacCallum’s paper, staining for islets and acinar cells
1912	Milne & Peters	R, C	PDL	acini and islets disappeared

GP: Guine pig, D: dog, R: rabbit, C: cat, Ch: Chicken, Hu: human, PDL: pancreatic ductal ligation, PPx: partial pancreatectomy