Table 2.

Top-ranked transcription factor targets of microRNAs in colon tumors from rats given PhIP+spinach (Metacore Pathway Analysis)

Key network objects	Total nodes	Seed nodes	p-value	g-score
c-Myc	6	5	2.30e-18	130.77
p53	6	5	2.30e-18	130.77
TBP	4	3	4.60e-11	96.09
ESR1	4	3	4.60e-11	96.09
TCF8	4	3	4.60e-11	96.09
Oct-3/4	4	3	4.60e-11	96.09
SOX5	3	2	1.65e-07	73.97
Androgen receptor	3	2	1.65e-07	73.97
SIP1	3	2	1.65e-07	73.97
NRSF	3	2	1.65e-07	73.97
SOX6	3	2	1.65e-07	73.97
AML1 (RUNX1)	3	2	1.65e-07	73.97
c-Rel	3	2	1.65e-07	73.97
SOX2	3	2	1.65e-07	73.97
FKHR	3	2	1.65e-07	73.97
RREB1	2	1	4.87e-04	45.29
C/EBPα	2	1	4.87e-04	45.29
Elk-1	2	1	4.87e-04	45.29
MITF	2	1	4.87e-04	45.29
FOXO3A	2	1	4.87e-04	45.29