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. 2013 Sep 4;8(9):e73908. doi: 10.1371/journal.pone.0073908

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© 2013 Gonçalves et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Thyroid radioiodide uptake of rats treated with different flavonoids for five days (biochanin-A, catequin, fisetin, morin, naringenin, naringin, quercetin and rutin, 10mg/Kg body weight (BW), daily injections, sc.). Results are expressed as percentage of control group (n = 10 per group; *p < 0.05 vs. control); (B) Thyroid radioiodide uptake in rats treated with two different doses of rutin (10 or 20mg/Kg BW, daily injections, sc.) for five days. Results are expressed as percentage of control group (fold increase: rutin 10mg/Kg = 1.22; 20mg/Kg = 1.45; n = 15 per group; *p < 0.05 vs. control; **p < 0.01 vs. control); (C) Thyroid sodium-iodide symporter (NIS) protein levels in rats treated with 20mg/Kg BW rutin (daily injections, sc. for five days) (fold increase=1.34; n = 9 per group, *p < 0.05 vs. control); and (D) Thyroid NIS mRNA levels in rats treated with 20mg/Kg BW rutin (daily injections, sc. for five days) (fold increase=2.12; n = 10 per group, **p < 0.01 vs. control). GAPDH was used as internal control.