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. 2013 Sep 4;8(9):e73635. doi: 10.1371/journal.pone.0073635

Figure 2. Lrig2-deficient mice have increased spontaneous mortality and show transiently reduced body weight compared with wild-type and heterozygous littermates.

Figure 2

Kaplan-Meier curves for the survival of male (A) and female (B) C57BL/6 mice of the different Lrig2 genotypes based on 153 male and159 female mice. (C) There were no significant differences in embryonic weight at E13.5 or at birth, but by 5 days of age, the Lrig2E12-/- mice were significantly lighter than the Lrig2E12+/+ and Lrig2E12+/- mice (* p<0.05). Male (D) and female (E) Lrig2E12-/- mice had a lower body weight than the Lrig2E12+/+ and Lrig2E12+/- mice from 3 to 10 weeks of age. At 12 weeks of age, the male (F) (p = 0.019), but not the female (G) (p = 0.051), Lrig2E12-/- mice were significantly smaller than Lrig2E12+/+ and Lrig2E12+/- mice, and at 15 weeks or older, all genotypes had a similar body weight. At least eight mice were included per genotype and sex for all ages.