Figure 3. Pathway analysis on deregulated miRNAs in melanoma showed possible combinatorial effects on predicted gene pathways.

Interrogating the gene targets for down-regulated miRNAs in PCM vs. NS (A) and in PCM vs. CN (B) showed remarkable similarities in the pathways perturbed. The cutoff P-value was set at <0.00095. Common KEGG pathways shared between the two analyses are shown in the same color. Mitogen-activated protein kinase (MAPK) signaling pathway showed that several down-regulated miRNAs could converge on the same putative gene targets (C). The predicted miRNA targets are highlighted in yellow.