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. 2013 Sep 4;8(9):e73229. doi: 10.1371/journal.pone.0073229

Figure 1. Potential Interaction stages of p62 with LC3 species in the course of LC3 lipidation.

Figure 1

The known stages for LC3 lipidation are boxed. After translation pro-LC3B is processed by Atg4B by removing the last five amino acids to expose the G120 residue (LC3-I). A portion of LC3-I forms a complex with the E1-like enzyme Atg7 and subsequently generates a LC3-Atg7 conjugate. LC3-Atg7 then interacts with the E2-like enzyme Atg3 to form a LC3-Atg3 conjugate which interacts with Atg16L1:Atg5-Atg12 complex to convert to LC3-II under autophagic stimulation. p62 could potentially bind any LC3 specie at any stage of this process.