Table 3. ORs for gastric cancer cases stratified by histology and anatomic localization, in comparison with normal or non-atrophic gastritis, according to individual PSCA SNPs.

rs12155758
	GG		AG				AA					Dominant
Histological diagnoses	No.	OR	No.	OR	(95% CI)	P-value for difference	No.	OR	(95% CI)	P-value for difference	P-values for trend	OR	(95% CI)	P-value for difference
Normal/non-atrophic gastritis	409	–	491	–			156	–			–	–
Intestinal type	28	1	58	1.95	(1.14–3.32)	0.624	14	1.36	(0.64–2.88)	0.766	0.154	1.76	(1.07–3.00)	0.587
Diffuse and other type	18	1	47	2.38	(1.32–4.30)		11	1.61	(0.71–3.65)		0.073	2.18	(1.23–3.88)
Non-cardia cancer	42	1	94	2.08	(1.33–3.23)	0.626	22	1.41	(0.76–2.62)	0.618	0.06	1.90	(1.24–2.92)	0.586
Cardia cancer	4	1	11	2.87	(0.85–9.65)		3	2.18	(0.44–10.77)		0.201	2.69	(0.83–8.73)
rs2294008
	CC		CT				TT					Dominant
Normal/non-atrophic gastritis	231	–	507	–			319	–			–	–
Intestinal type	14	1	50	2.12	(1.05–4.27)	0.918	37	2.33	(1.12–4.84)	0.666	0.033	2.21	(1.13–4.30)	0.791
Diffuse and other type	9	1	36	2.24	(1.02–4.91)		32	2.96	(1.33–6.61)		0.007	2.53	(1.20–5.35)
Non-cardia cancer	21	1	75	2.06	(1.15–3.69)	0.500	64	2.61	(1.43–4.76)	0.933	0.002	2.28	(1.32–3.96)	0.690
Cardia cancer	2	1	11	3.72	(0.74–18.65)		5	2.41	(0.42–13.92)		0.459	3.20	(0.66–15.41)

Odds ratios were adjusted for age, gender, smoking status, length of refrigerator use, educational level. Values in bold are statistically significant (p<0.004), in italic p-value<0.017 (p = 0.05/3 polymorphisms).