Table 4. ORs for pre-neoplastic lesions and gastric cancer cases stratified by diagnosis and cagA status, in comparison with normal or non-atrophic gastritis, according to individual PSCA SNPs.
Normal/non-atrophic gastritis | Atrophic gastritis | Intestinal metaplasia+Dysplasia | Cancer | ||||||||
Genotypes | cagA | No. | No | OR | (95% CI) | No. | OR | (95% CI) | No. | OR | (95% CI) |
rs12155758 | |||||||||||
GG | + | 231 | 80 | 1.00 | 189 | 1.00 | 31 | 1.00 | |||
AG/AA | 329 | 133 | 1.20 | (0.84–1.61) | 332 | 1.20 | (0.96–1.60) | 95 | 2.20 | (1.34–3.68) | |
GG | – | 178 | 35 | 1.00 | 59 | 1.00 | 15 | 1.00 | |||
AG/AA | 318 | 67 | 1.10 | (0.70–1.74) | 77 | 0.77 | (0.52–1.15) | 35 | 1.69 | (0.78–3.63) | |
P-values for interaction between SNP and cagA status | 0.818 | 0.046 | 0.443 | ||||||||
rs2294008 | |||||||||||
CC | + | 136 | 40 | 1.00 | 82 | 1.00 | 16 | 1.00 | |||
CT/TT | 427 | 176 | 1.40 | (0.94–2.09) | 443 | 1.80 | (1.29–2.42) | 112 | 2.40 | (1.25–4.43) | |
CC | – | 95 | 13 | 1.00 | 28 | 1.00 | 7 | 1.00 | |||
CT/TT | 399 | 89 | 1.70 | (0.88–3.18) | 110 | 1.03 | (0.63–1.68) | 43 | 2.55 | (0.90–7.27) | |
P-values for interaction between SNP and cagA status | 0.720 | 0.056 | 0.986 |
Odds ratios were adjusted for age, gender, smoking status, length of refrigerator use, educational level. cagA negative includes subjects who were not infected by H. pylori (187 subjects)and subjects who were infected by H. pylori but carried a cagA-negative strain (604 subjects). Values in bold are statistically significant (p<0.004), in italic p-value<0.017 (p = 0.05/3 polymorphisms).