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. 2013 Sep 4;8(9):e73100. doi: 10.1371/journal.pone.0073100

Table 4. ORs for pre-neoplastic lesions and gastric cancer cases stratified by diagnosis and cagA status, in comparison with normal or non-atrophic gastritis, according to individual PSCA SNPs.

Normal/non-atrophic gastritis Atrophic gastritis Intestinal metaplasia+Dysplasia Cancer
Genotypes cagA No. No OR (95% CI) No. OR (95% CI) No. OR (95% CI)
rs12155758
GG + 231 80 1.00 189 1.00 31 1.00
AG/AA 329 133 1.20 (0.84–1.61) 332 1.20 (0.96–1.60) 95 2.20 (1.34–3.68)
GG 178 35 1.00 59 1.00 15 1.00
AG/AA 318 67 1.10 (0.70–1.74) 77 0.77 (0.52–1.15) 35 1.69 (0.78–3.63)
P-values for interaction between SNP and cagA status 0.818 0.046 0.443
rs2294008
CC + 136 40 1.00 82 1.00 16 1.00
CT/TT 427 176 1.40 (0.94–2.09) 443 1.80 (1.29–2.42) 112 2.40 (1.25–4.43)
CC 95 13 1.00 28 1.00 7 1.00
CT/TT 399 89 1.70 (0.88–3.18) 110 1.03 (0.63–1.68) 43 2.55 (0.90–7.27)
P-values for interaction between SNP and cagA status 0.720 0.056 0.986

Odds ratios were adjusted for age, gender, smoking status, length of refrigerator use, educational level. cagA negative includes subjects who were not infected by H. pylori (187 subjects)and subjects who were infected by H. pylori but carried a cagA-negative strain (604 subjects). Values in bold are statistically significant (p<0.004), in italic p-value<0.017 (p = 0.05/3 polymorphisms).