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. 2013 Sep 4;8(9):e72912. doi: 10.1371/journal.pone.0072912

Table 3. Rapid diagnostic test (RDT) sensitivity, specificity, positive and negative predictive value against polymerase chain reaction (PCR) and blood smear (BS) microscopy.

PCR + PCR – Total BS+ BS− Total
RDT + 117 4 121 110 11 121
RDT – 7* 726* 733 6** 733** 739
Total 124 730 854 116 744 860
Sensitivity 76.5% (95% CI 69.0– 83.9%) 78.6% (95% CI 70.8–85.1)
Specificity 99.9% (95% CI 99.7– 100%) 99.7% (95% CI 99.5–99.9%)
Positive predictive value 96.7% (95% CI 91.8– 99.1%) 91.7% (95% CI 84.3–95.4%)
Negative predictive value 99.0% (95% CI 98.0– 99.6%) 99.2% (95% CI 98.8–99.5%)
*

For calculations of sensitivity and specificity the absolute numbers in the RDT negative group were multiplied with a factor of 5.14 to account for that only a sub-sample, i.e. 733 of 3768, in this group were subjected to blood sampling on filter paper for PCR.

**

For calculations of sensitivity and specificity the absolute numbers in the RDT negative group were multiplied with a factor of 5.01 to account for that only a sub-sample, i.e. 739 of 3768, in this group were subjected to blood sampling for BS microscopy.