Table 3. Rapid diagnostic test (RDT) sensitivity, specificity, positive and negative predictive value against polymerase chain reaction (PCR) and blood smear (BS) microscopy.
PCR + | PCR – | Total | BS+ | BS− | Total | |
RDT + | 117 | 4 | 121 | 110 | 11 | 121 |
RDT – | 7* | 726* | 733 | 6** | 733** | 739 |
Total | 124 | 730 | 854 | 116 | 744 | 860 |
Sensitivity | 76.5% (95% CI 69.0– 83.9%) | 78.6% (95% CI 70.8–85.1) | ||||
Specificity | 99.9% (95% CI 99.7– 100%) | 99.7% (95% CI 99.5–99.9%) | ||||
Positive predictive value | 96.7% (95% CI 91.8– 99.1%) | 91.7% (95% CI 84.3–95.4%) | ||||
Negative predictive value | 99.0% (95% CI 98.0– 99.6%) | 99.2% (95% CI 98.8–99.5%) |
For calculations of sensitivity and specificity the absolute numbers in the RDT negative group were multiplied with a factor of 5.14 to account for that only a sub-sample, i.e. 733 of 3768, in this group were subjected to blood sampling on filter paper for PCR.
For calculations of sensitivity and specificity the absolute numbers in the RDT negative group were multiplied with a factor of 5.01 to account for that only a sub-sample, i.e. 739 of 3768, in this group were subjected to blood sampling for BS microscopy.