Table 1. Historic data on metabolite characterization of human urine by different platforms.

Method(s)	# Identified	# Quantified	Year	Reference
Multiple	51	51	1971	Putnam [105]
GC-MS	52	0	1976	Lawson [85]
GC-MS	72	72	1978	Gates [106]
GC-MS	36	36	1989	Hoffman [107]
GC-MS	137	0	1990	Liebich [108]
GC-MS	131	95	1991	Shoemaker [84]
GC-MS	69	69	1994	Guneral [56]
GC-MS	75	75	1996	Matsumoto [109]
ICP-MS	33	33	2005	Goulle [110]
SPE/NMR	73	0	2008	Yang [40]
SPE/LC/NMR	72	0	2008	Rezzi [78]
LC-MS/NMR	50	0	2008	Law [34]
LC-MS	93	93	2009	Guo [111]
NMR	50	50	2009	Shaykhutdinov [112]
GC-MS-MS	48	48	2011	Kvitvang [113]
SPE-GC-MS	79	0	2011	Silva [114]
LC-MS	167	0	2011	Guo [115]
NMR	42	42	2011	Saude [116]
NMR/GC-MS	77	0	2012	Zhang [117]
LC-MS	219 (25 listed)	0	2012	Van der Kloet [118]
GC-TOF/LC-MS	261	0	2012	Cheng [119]
GC-MS	258	0	2012	Roux [83]
GCxGC-TOF-MS	294	0	2012	Rocha [120]