Table 3. Univariate a Predictors of Cord and Three Year DNA Methylation (continuous).
Cord DNA Methylation (ng/100ng total DNA) | Cord DNA Methylation (subset)b (ng/100ng total DNA) | Three Yr DNA Methylation (ng/100ng total DNA) | ||||||||
N | Statistical estimate | p- value | N | Statistical estimate | p-value | Statistical estimate | p-value | |||
Maternal Ht | 277 | beta | −0.003 | 0.889 | 165 | beta | 0.020 | 0.487 | −0.035 | 0.194 |
rho | −0.018 | 0.770 | rho | 0.045 | 0.570 | −0.066 | 0.400 | |||
Pre-preg. Wt. | 270 | beta | −0.004 | 0.018 | 159 | beta | −0.005 | 0.055 | −0.009 | 0.000 |
rho | −0.125 | 0.040 | rho | −0.199 | 0.012 | −0.315 | 0.000 | |||
Pre-preg. BMI | 269 | beta | −0.023 | 0.029 | 159 | beta | −0.033 | 0.027 | −0.049 | 0.000 |
rho | −0.124 | 0.043 | rho | −0.234 | 0.003 | −0.293 | 0.000 | |||
Weight gain | 252 | beta | 0.003 | 0.433 | 152 | beta | 0.007 | 0.265 | 0.000 | 0.986 |
rho | 0.050 | 0.434 | rho | 0.037 | 0.651 | −0.086 | 0.293 | |||
Maternal age | 279 | beta | −0.005 | 0.743 | 165 | beta | −0.023 | 0.229 | −0.038 | 0.040 |
rho | −0.040 | 0.502 | rho | −0.184 | 0.018 | −0.176 | 0.023 | |||
Total PAH | 268 | beta | 0.076 | 0.361 | 159 | beta | 0.080 | 0.524 | −0.067 | 0.576 |
rho | −0.03 | 0.66 | rho | 0.076 | 0.344 | −0.095 | 0.235 |
Univariate a Continuous Predictors of Log-transformed Cord and Three Year DNA Methylation, Beta and Correlation Coefficients.
Regression analyses corrected for inter-plate variation.
The ‘subset’ includes children who have contributed both cord and three year DNA samples.
Abbreviations: Yr (year); Ht (height); Wt (weight); BMI (Body Mass Index); PAH (Polycyclic Aromatic Hydrocarbons).