Table 3. Distribution of gene state alterations caused by p53 removal and DNA damage from in silico logical steady state analysis.

Source scenario	Target scenario	Number of up-regulated genes	Number of unchanged genes	Number of down-regulated genes
P53 wild type with DNA damage	P53 mutant with DNA damage	29(14%)	113(56%)	60(30%)
P53 wild type without DNA damage	P53 mutant with DNA damage	30(15%)	112(55%)	60(30%)
P53 wild type with DNA damage	P53 wild type without DNA damage	5(2%)	185(92%)	12(6%)
P53 mutant with DNA damage	P53 mutant without DNA damage	7(3%)	181(90%)	14(7%)

The distribution of 202 p53-interacting genes with different changes between four scenarios was calculated using logical steady state analysis.