Skip to main content
. Author manuscript; available in PMC: 2013 Sep 4.
Published in final edited form as: Pharmacol Biochem Behav. 2008 Oct;90(4):753–757. doi: 10.1016/j.pbb.2008.06.002

Figure 1.

Figure 1

First-encounter social investigative behaviors in mice and the impact of MK-801. Test mice (adult male ICR) were placed in the testing arena to acclimate for 15 min, followed by i.p. injection of either saline or MK-801 (0.1 mg/kg), and placed in home cage for 30 min. First encounter began when a test mouse and a companion mouse (juvenile male ICR) were placed into the test arena at the same time. Animals were allowed to move and interact freely, and were videotaped for 5 min. The video was analyzed offline for various behaviors of the test mouse only. Data are shown as mean ± SEM (n = 12 – 13). Open boxes: saline-injected control mice. Closed boxes: MK-801-injected mice. *, significant difference (p < 0.05) between MK-801 mice and saline controls (Student's un-paired t-test). Top row: individual-oriented behaviors; bottom row: social behaviors.