Table 2.
Somatic BRAF mutations identified
| Exon | Nucleotide change | Amino acid change | Frequency, N |
|---|---|---|---|
| 11 | 1391G>A | G464Ea | 1 |
| 1391G>T | G464Vb | 1 | |
| 1396G>A | G466R | 1 | |
| 1397G>T | G466Vc | 4 | |
| 1406G>C | G469A | 2 | |
| 1405_1407delGGA | G469del | 1 | |
| 1406G>T | G469V | 1 | |
| 15 | 1780G>A | D594N | 1 |
| 1781A>G | D594G | 2 | |
| 1801A>G | K601E | 1 | |
| 1794_1796dupTAC | T599_V600insT | 1 | |
| 1799_1801delTGA | V600_K601delinsE | 1 | |
| 1799T>A | V600Ed | 18 | |
| 1798G>T | V600L | 1 |
a
One patient had both BRAF G464E and KRAS G12A
b
One patient had both BRAF G464V and KRAS G13C
c
One patient had both BRAF G466V and KRAS G12C
d
One patient had both BRAF V600E and PIK3CA E545K
Abbreviations: del, deletion; ins, insertion; dup, duplication