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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Cerebellum. 2013 Oct;12(5):692–706. doi: 10.1007/s12311-013-0476-9

Figure 5. Artificial SK Conductance (GSK-art) inserted via dynamic clamp can recover spontaneous behavior of CN neurons after SK block by apamin.

Figure 5

A: Spontaneous activity of a CN neuron before (black) and after presentation of 100 nM apamin (red). B: Restored spontaneous activity by artificial SK conductance (GSK-art) applied via dynamic clamp following apamin superfusion. From top to bottom, locked in time: (i) voltage response (blue) similar to baseline spontaneous activity, (ii) simulated high voltage activated (HVA) Ca2+ current (brown), (iii) simulated intracellular [Ca2+] (purple), (iv) simulated GSK-art (green), and (v) injected artificial SK current (ISK-art) (orange).