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. Author manuscript; available in PMC: 2014 Sep 27.
Published in final edited form as: Free Radic Biol Med. 2013 Mar 27;0:95–110. doi: 10.1016/j.freeradbiomed.2013.03.015

Table 1.

Targets of SIRT1 which are regulated under oxidative stress

SUBSTRATES/TARGETS FUNCTIONS
Histones
H1K26, H3K9, H3K14, H3K56, H4K16		 Reduces T cell activation, reduces transcriptional silencing, role in innate and adaptive immune function.
Non-histones
p53, RelA/p65, FOXO3, STAT3, p73, E2F1, PTEN, Bax, HIF-1α, HIF-2α, β-catenin, PGC1α, CLOCK, BMAL1, Per2, Ku70, SMAD7, TORC2, p300, SUV39H1, PPARγ		 DNA damage and repair response, oxidative stress response, autophagy, energy metabolism, cell cycle, cell survival, growth arrest, apoptosis, immune function, inflammation, circadian rhythm, NF-κB, NOTCH, WNT, TGF-β-induced signaling, insulin sensitivity and signaling, genomic stability, mitochondrial biogenesis, and adipogenesis.