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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: Free Radic Biol Med. 2012 Oct 22;53(12):10.1016/j.freeradbiomed.2012.10.536. doi: 10.1016/j.freeradbiomed.2012.10.536

Fig. 7.

Fig. 7

Proposed model of IR-mediated bone loss in the absence of Nrf2. Exposure to IR negatively affects osteoblast differentiation. A large pool of undifferentiated osteoblasts may increase the amount of RANKL secreted and induce osteoclastic bone resorption. In addition, increased oxidative stress in absence of Nrf2 may also contribute to the differentiation and maturation of osteoclasts.