Table 2.
Associations between Patient Characteristics and EGFR and KRAS Mutation Status
| EGFR Mutation Status | KRAS Mutation Status | |||||
|---|---|---|---|---|---|---|
| Variable | # positive/# tested | % | Fisher’s exact P value | # positive/# tested | % | Fisher’s exact P value |
| Gender | 0.002 | 0.03 | ||||
| Female | 47/220 | 21.4 | 58/173 | 33.5 | ||
| Male | 13/143 | 9.1 | 25/117 | 21.4 | ||
| Race | <0.001 | 0.05 | ||||
| Caucasian | 47/287 | 16.4 | 72/224 | 32.1 | ||
| African American | 3/47 | 6.4 | 8/40 | 20.0 | ||
| Asian American | 9/12 | 75.0 | 0/11 | 0.0 | ||
| Other | 0/12 | 0.0 | 2/10 | 20.0 | ||
| Smoking status | <0.001 | <0.001 | ||||
| Never smoker | 36/75 | 48.0 | 4/56 | 7.1 | ||
| Ever smoker | 24/286 | 8.4 | 78/232 | 33.6 | ||
| ECOG PS | 0.54+ | 0.52+ | ||||
| 0 | 20/121 | 16.5 | 25/99 | 25.3 | ||
| 1 | 24/143 | 16.8 | 36/125 | 28.8 | ||
| 2+ | 3/32 | 9.4 | 8/26 | 30.8 | ||
| Histology | 0.15 | 0.42 | ||||
| AdenoCA ±BAC | 53/287 | 18.5 | 70/228 | 30.7 | ||
| Squamous | 6/28 | 21.4 | 3/22 | 13.6 | ||
| Adenosquamous | 0/14 | 0.0 | 4/11 | 36.4 | ||
| NOS* | 1/20 | 5.0 | 3/17 | 17.6 | ||
| Large Cell | 0/8 | 0.0 | 2/7 | 28.6 | ||
| Other$ | 0/3 | 0.0 | 0/2 | 0.0 | ||
| Stage | 0.73+ | 0.23+ | ||||
| I | 9/43 | 20.9 | 11/29 | 37.9 | ||
| II | 5/33 | 15.2 | 9/27 | 33.3 | ||
| III | 17/115 | 14.8 | 25/93 | 26.9 | ||
| IV | 29/172 | 16.9 | 38/141 | 27.0 | ||
| Brain Metastases | 0.50 | 0.37 | ||||
| No | 49/281 | 17.4 | 66/219 | 30.1 | ||
| Yes | 11/81 | 13.6 | 17/70 | 24.3 | ||
| Liver Metastases | 0.04 | 0.18 | ||||
| No | 58/323 | 18.0 | 76/252 | 30.2 | ||
| Yes | 2/39 | 5.1 | 7/37 | 18.9 | ||
| Subcutaneous Metastases | 0.60 | 0.07 | ||||
| No | 60/357 | 16.8 | 80/285 | 28.1 | ||
| Yes | 0/5 | 0.0 | 3/4 | 75.0 | ||
| Bone Metastases | 0.28 | 0.15 | ||||
| No | 39/257 | 15.2 | 65/208 | 31.2 | ||
| Yes | 21/105 | 20.0 | 18/81 | 22.2 | ||