Table 1.
Characteristics of subjects with WAGR Syndrome, isolated aniridia, and healthy controls. Mean ± standard deviation (range) or percentage shown.
| WAGR Syndrome (n=28) | Isolated Aniridia (n=12) | Healthy Controls (n=20) | P-Values | ||||
|---|---|---|---|---|---|---|---|
| Overall | WAGR vs. Aniridia | WAGR vs. Healthy | Aniridia vs. Healthy | ||||
| Age (y) | 14.8 ± 7.5 (6.1–28.3) | 28.9 ± 13.4 (7.3–54.0) | 15.3 ± 7.3 (4.1–32.8) | <.001 | <.001 | 1.00 | <.001 |
| Sex (% Female) | 60.7 | 50.0 | 60.0 | .81 | .73 | 1.00 | .72 |
| Race/Ethnicity (%) | .26 | .74 | .15 | .32 | |||
| Non-Hispanic Caucasian | 89.2 | 91.7 | 60.0 | ||||
| Hispanic Caucasian | 3.6 | 0 | 5.0 | ||||
| African American | 0 | 0 | 10.0 | ||||
| Asian | 3.6 | 0 | 15.0 | ||||
| Mixed Race | 3.6 | 8.3 | 10.0 | ||||
| Visual Acuity Score | 4.3 ± 1.3 (2–7) | 4.0 ± 1.4 (2–7) | all = 1.0 | <.001 | .53 | <.001 | <.001 |
| Vineland Adaptive Behaviour Composite Score | 62 ± 16 (20–90) (n=28) |
81 ± 19 (37–99) (n=8) |
105 ± 7 (91–117) (n=13) |
<.001 | .009 | <.001 | .002 |
| Composite IQ/DQ | 58 ± 24 (16–121) (n=24) |
101 ± 11 (86–117) (n=10) |
113 ± 13 (92–138) (n=20) |
<.001 | <.001 | <.001 | .29 |