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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Eur J Pain. 2013 May 7;17(10):1458–1464. doi: 10.1002/j.1532-2149.2013.00326.x

Figure 1. Development of below-level hypersensitivity to mechanical stimulation in some SCI rats.

Figure 1

The 50% paw withdrawal thresholds to von Frey filament stimulation were examined at the hind paws of SCI rats at designated time points. In sham rats, the hindpaw thresholds were between 10-15 grams, similar to the pre-surgery level of naïve rats. Behavioral hyperreflexia as indicated by reduced paw withdrawal thresholds to von Frey filament stimulation (around or below 5 g) was developed in the hindpaws of approximately half of the SCI rats. Another half of the SCI rats had hindpaw sensitivity similar to that from the sham control. Data presented are the means ± SEM from 34 rats in the pre-SCI groups, 15 rats in the sham group, 23 and 25 rats each in the hyperreflexic or non-hyperreflexic groups, respectively. **p < 0.01, ***p < 0.001 compared with the non-hyperreflexic group; #p < 0.05, ###p < 0.001 compared with day 10 post injury as determined by two-way ANOVA analyses.